By definition to get a Repetitive Stress Injury (RSI) you have to make be doing some repetitive motion, like using a computer mouse. I’ve tried mouse pad wrist support, but those just forced me to bend my wrist more because my arm was anchored to the support. I’ve tried switching hands for a few days and it helps but it’s very distracting. Then I had an aha moment that addresses the root cause and changes the motions that you make with your arm/wrist:
Change the mouse speed, every now and then.
The speed difference forces you to have to either move your whole arm or just move the mouse with your finger tips (i find this is easiest with a small form factor wireless mouse like this one Microsoft Optical Wireless 4000 and a nice mouse pad, like the pro gamer ones Fragmat.
Oh and for the love of god don’t enable pointer trails, its soooo Win 3.11